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鱼类免疫与寄生虫

鱼类免疫与寄生虫
 

学科带头人：聂品 (Nie, Pin)

学科组介绍：
鱼类免疫学与寄生虫学学科组主要从事低等脊椎动物免疫学和病原生物学方面的基础研究，发展可用于水产动物病害防治的疫苗研制的理论和技术，新世纪星空体育彩票成为维拉亚洲区官方合作伙伴百千万人才工程入选者。因此固定人员包括：鱼类对病原的免疫反应规律；2）以鱼类寄生虫和血吸虫为对象，毒力因子基因缺失突变株的构建。学科组负责人聂品研究员为湖北省有突出贡献中青年专家，研究寄生后生动物的致病机理、种群生态及其与宿主的协同进化；3）鱼类细菌性病原的毒力因子、毒力的鉴定与致病机理，近期的研究活动主要在于：1）鱼类免疫器官和免疫细胞的组成、个体发生，特异和非特异性免疫分子的基因、纯化以及功能，疫苗侯选基因的筛选，谢海侠研究员、李楠博士和姚卫建高级实验师。

联系方式：027 68780736, 027 68780005，Email: pinnie@ihb.ac.cn 
地点：新实验大楼504-509

仪器设备：Nikon解剖镜, Olympus显微镜, PCR仪, 冷冻离心机, 双向电泳系统, 凝胶成像系统, 杂交箱, 蛋白纯化仪, 蛋白测序仪。

近三年发表文章： 

  1. Zhang S H; Zhao Q P; Jiao R; Gao Q; Nie P.Identification of polymorphic microsatellites for the intermediate host Oncomelania hupensis of Schistosoma japonicum in China.Malacologia (in press).
  2. Xu Q Q; Chang M X; Sun R H; Xiao F S; Nie P. The first non-mammalian CXCR5 in a teleost fish: molecular cloning and expression analysis in grass carp (Ctenopharyngodon idella). BMC immunology 2010 (in press).
  4. Chen D L; Guo X G; Nie P.Phylogenetic studies of sinipercid fish (Perciformes: Sinipercidae) based on multiple genes, with first application of an immune-related gene, the virus-induced protein (viperin) gene.Molecular phylogenetics and evolution 2010; 55, 1167-1176.
  5. Qi Z T; Nie P; Secombes C J; Zou J.Intron-containing Type I and Type III IFN coexist in amphibians: Refuting the concept that a retroposition event gave rise to Type I IFNs.Journal of immunology 2010; 184, 5038-5046.
  6. Zhao Q P; Jiang M S; Littlewood D T J; Nie P.Distinct genetic diversity of Oncomelania hupensis, intermediate host of Schistosoma japonicum in mainland China as revealed by ITS sequences.PLoS neglected tropical diseases 2010; 4: e611.
  8. Xu Qiao Q; Chang Ming X; Xiao Fan S; Huang Bei; Nie P. The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Veterinary immunology and immunopathology 2010; 134(3-4):269-78.
  9. Chen W Q; Xu Q Q; Chang M X; Zou J; Secombes C J; Peng K M; Nie P. Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gammarel) in grass carp Ctenopharyngodon idella. Veterinary immunology and immunopathology 2010; 134(3-4):199-207.
  12. Tian J Y; Xie H X; Zhang Y A; Xu Z; Yao W J; Nie P. Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsiidentified by in situ hybridisation. Veterinary immunology and immunopathology 2009; 132(2-4):146-52.
  13. Xiong Fan; Wang Gui Tang; Wu Shan Gong; Nie P. Development of Eustrongylidesignotus(Nematoda: Dioctophmida) in domestic ducks (Anas platyrhynchosdomestica(L.)). The Journal of parasitology 2009; 95(5):1035-9.
  14. Xu Z; Chang M X; Qi Z T; Huang B; Nie P. Immunoglobulin joining (J) chain and its expression in the Chinese soft-shelled turtle (Pelodiscus sinensis). Veterinary immunology and immunopathology 2009; 131(3-4):268-72.
  15. Gao Q; Nie P; Thompson K D; Adams A; Wang T; Secombes C J; Zou J. The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Developmental and comparative immunology 2009; 33(8):920-31.
  16. Xu Zhen; Wang Gai L; Nie P. IgM, IgD and IgY and their expression pattern in the Chinese soft-shelled turtle Pelodiscus sinensis. Molecular immunology 2009; 46(10):2124-32.
  18. Chang M X; Wang Y P; Nie P. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish & shellfish immunology 2009; 26(2):264-74.
  19. Liu Y; Chang M X; Wu S G; Nie P. Characterization of C-C chemokine receptor subfamily in teleost fish. Molecular immunology 2009; 46(3):498-504.
  20. Zou Jun; Chang Mingxian; Nie P; Secombes Chris J. Origin and evolution of the RIG-I like RNA helicase gene family. BMC evolutionary biology 2009; 9:85.
  25. Liu G Y; Nie P; Zhang J; Li N. Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Flavobacterium columnare. Journal of fish diseases 2008; 31(4):269-76.
  26. Gao Dian; Wang Gui Tang; Xi Bing Wen; Yao Wei Jian; Nie P. A new species of Allocreadium(Trematoda: Allocreadiidae) from freshwater fishes in the Danjiangkou Reservoir in China. The Journal of parasitology 2008; 94(1):176-80.
  27. Song Y; Wang G T; Yao W J; Gao Q; Nie P. Phylogeny of freshwater parasitic copepods in the Ergasilidae (Copepoda: Poecilostomatoida) based on 18S and 28S rDNA sequences. Parasitology research 2008; 102(2):299-306.
  28. Xu Z Y; Sun B J; Chang M X; Nie P. Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary immunology and immunopathology 2008; 121(1-2):44-57.
  29. Harun Nor Omaima; Zou Jun; Zhang Yang-An; Nie P; Secombes Chris J. The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8. Developmental and comparative immunology 2008; 32(6):673-81.
  30. Xu Zaiyan; Nie P; Sun Baojian; Chang M X. Molecular identification and expression analysis of tumor necrosis factor receptor-associated factor 2 in grass carp Ctenopharyngodon idella. Acta biochimica et biophysica Sinica 2007; 39(11):857-68.
  36. Gao Q; X Chen M; Yao W J; Gao Y; Song Y; Wang G T; Wang M X; Nie P. Phylogeny of diplozoids in five genera of the subfamily Diplozoinae Palombi, 1949 as inferred from ITS-2 rDNA sequences. Parasitology 2007; 134(Pt 5):695-703.
  38. Sun B J; Chang M X; Song Y; Yao W J; Nie P. Gene structure and transcription of IRF-1 and IRF-7 in the mandarin fish Siniperca chuatsi. Veterinary immunology and immunopathology 2007; 116(1-2):26-36.

(last updated 9th May, 2010)


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细胞工程育种研究室 / 水产抗逆与病害防控研究室 / 科研部门 / 水产养殖与绿色渔业研究室 / ARP登录

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