论文

论文标题：
作者：
出版刊物：
出版日期：
出版年份：
卷/期：
DOI：
论文摘要：	Grass carp hemorrhagic disease, caused by the grass carp reovirus (GCRV), is a major disease that hampers the development of grass carp aquaculture in China. The mechanism underlying GCRV infection is still largely unknown. Circular RNAs (circRNAs) are important regulators involved in various biological processes. In the present study, grass carp were infected with GCRV, and spleen samples were collected at 0 (control), 1, 3, 5, and 7 days post-infection (dpi). Samples were used to construct and sequence circRNA libraries, and a total of 5052 circRNAs were identified before and after GCRV infection, of which 41 exhibited differential expression compared with controls. Many parental genes of the differentially expressed circRNAs are involved in metal ion binding, protein ubiquitination, enzyme activity, and nucleotide binding. Moreover, 72 binding miRNAs were predicted from the differentially expressed circRNAs, of which eight targeted genes were predicted to be involved in immune responses, blood coagulation, hemostasis, and complement and coagulation cascades. Upregulation of these genes may lead to endothelial and blood cell damage and hemorrhagic symptoms. Our results indicate that an mRNA-miRNA-circRNA network may be present in grass carp infected with GCRV, providing new insight into the mechanism underlying grass carp reovirus infection.

Copyright 2009 © 星空体育彩票最新版下载 All Rights Reserved
地址：武汉市武昌东湖南路7号电话：027-68780839　星空体育彩票最新版下载
鄂ICP备050003091号-1 鄂公网安备42010602002652号

继续阅读

以下内容与「星空体育彩票最新版下载」同属公开资讯，可按栏目接着查阅相关条目。

本站按公开材料组织页面。需要原文时请核对应栏目发布页。

若从搜索引擎进入，可先确认当前栏目名称，再按需打开相关阅读。