论文

论文标题：
作者：
出版刊物：
出版日期：
出版年份：
卷/期：
DOI：
论文摘要：	Evolutionarily conserved E2F family transcription factors regulate the cell cycle via controlling gene expression in a wide range of eukaryotes. We previously demonstrated that the meiosis-specific transcription factor E2fl1 had an important role in meiosis in the model ciliate Tetrahymena thermophila. Here, we report that expression of another E2F family transcription factor gene DPL2 correlates highly with that of E2FL1. Similar to e2fl1 Delta cells, dpl2 Delta cells undergo meiotic arrest prior to anaphase I, with the five chromosomes adopting an abnormal tandem arrangement. Immunofluorescence staining and immunoprecipitation experiments demonstrate that Dpl2 and E2fl1 form a complex during meiosis. We previously identified several meiotic regulatory proteins in T. thermophila. Cyc2 and Tcdk3 may cooperate to initiate meiosis and Cyc17 is essential for initiating meiotic anaphase. We investigate the relationship of these regulators with Dpl2 and E2fl1, and then construct a meiotic regulatory network by measuring changes in meiotic genes expression in knockout cells. We conclude that the E2fl1/Dpl2 complex plays a central role in meiosis in T. thermophila.

Copyright 2009 © 星空体育彩票注册优惠 All Rights Reserved
地址：武汉市武昌东湖南路7号电话：027-68780839　星空体育彩票注册优惠
鄂ICP备050003091号-1 鄂公网安备42010602002652号

继续阅读

以下内容与「星空体育彩票注册优惠」同属公开资讯，可按栏目接着查阅相关条目。

本站按公开材料组织页面。需要原文时请核对应栏目发布页。

若从搜索引擎进入，可先确认当前栏目名称，再按需打开相关阅读。