| 论文标题： | |
|---|---|
| 作者： | |
| 出版刊物： | |
| 出版日期： | |
| 出版年份： | |
| 卷/期： | |
| DOI： | |
| 论文摘要： | Flavobacterium columnare is an important pathogen causing columnaris disease, which can result in high mortality in freshwater fish worldwide. Understanding the immune response in infection status of fish may be essential for developing effective prevention and treatment strategies. In this study, transcriptomes of liver and head kidney tissues in grass carp (Ctenopharyngodon idella) were compared under symptomatic and asymptomatic statuses following the immersion infection of F. columnare. Significant differences in expression of genes were observed between fish showing disease symptoms and those without symptoms. The number of differentially expressed genes (DEGs) between infected and control groups ranged from 4752 to 8,277, while the DEGs between exposed and control groups ranged from 272 to 1,751, suggesting a strong acute inflammatory response in infected groups. KEGG pathway enrichment analysis of infected groups revealed that among the top 30 enriched pathways, liver and head kidney shared 22 and 16 common pathways, respectively. These common enriched pathways are involved in various functions such as metabolism, diseases, cellular processes, biological systems, and information processing, indicating their roles in the immune response to F. columnare. Notably, we investigated in detail the gene expression profiles associated with complement molecules and three classes of cytokines (interleukin, tumor necrosis factor, and interferon) in different organs/tissues and disease states during the pathogenesis of columnaris disease. The findings highlight the importance of inflammatory responses and complement pathways in the pathogenesis of columnaris disease and suggest potential targets for future research and disease management strategies. The present study thus provides valuable insights into the transcriptomic changes and immune responses in grass carp infected with F. columnare, and sheds light on how highly virulent strains of F. columnare cause morbidity and mortality in the host. |
以下内容与「星空体育彩票官网优惠活动」同属公开资讯，可按栏目接着查阅相关条目。
本站按公开材料组织页面。需要原文时请核对应栏目发布页。
若从搜索引擎进入，可先确认当前栏目名称，再按需打开相关阅读。
