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| 论文摘要： | Grass carp reovirus (GCRV) causes hemorrhagic disease leading to substantial economic losses to the aquaculture industry of grass carp. Effective artificial virus infection methods are essential for the disease-resistant breeding programs and vaccines development. In our study, we established four distinct artificial infection methods for GCRV to identify the most effective approach for inducing infection in grass carp. These methods included feeding, gavage, immersion, and injection. Each method resulted in a similar mortality rate of approximately 80 % and induced characteristic hemorrhagic symptoms associated with GCRV infection. The viral replication patterns were consistent across all infection methods in eight examined tissues, with the intestine, brain, liver, and muscle identified as particularly susceptible to GCRV infection. Furthermore, all artificial infection methods led to significant pathological alterations in the liver and intestinal tissues. Notably, a large number of GCRV viral particles were observed in the kidneys of the infected groups but not present in the control groups. These results underscore the efficacy of the four artificial infection methods evaluated. The choice of the optimal infection method should be tailored to specific conditions. Our findings provide valuable insights for disease- resistant breeding and vaccines development, thereby contributing to the sustainability of the aquaculture industry. |
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