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| 论文摘要： | The Yangtze finless porpoise (YFP), a critically endangered small odontocete species, is mostly living in the lower and middle sections of the Yangtze River and its two big adjacent lakes. The YFP population experienced a drastic decline due to the threats from various human activities. Comprehending their biology, particularly the immune changes associated with aging, is essential for ensuring their protection. The study aimed to identify genes and pathways in thirteen YFPs blood that are influenced by age, revealing their immune system's susceptibility to aging and reduced disease response. The current research utilized RNA-Seq to find differentially expressed genes (DEGs) in blood tissues, and we screened 478, 442, and 739 DEGs in comparison groups of calf vs. adult, calf vs. old, and adult vs. old, respectively. STEM, GO and KEGG enrichment analyses revealed significant changes in metabolism, immune-related, development, signal transduction pathways, and aging among the three age-related groups. In the calf vs. adult group, the DEGs were mainly associated with primary immunodeficiency, IgA production, and B cell receptor signaling pathways. In the calf vs. old group, the DEGs were significantly enriched in autoimmune disease, cytokine interactions, and viral/bacterial infections. In the adult vs. old group, the DEGs were primarily linked to cytokine interactions and bile secretion. The current study identifies DEGs affecting immunity, development, and growth in YFPs by comparing blood transcriptomes of calves, adults, and old YFPs. This information provides a basis for studying YFP's development, growth, and aging and will guide future research on disease prevention, treatment strategies, management, and conservation of YFP. |
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