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| 论文摘要： | The Chinese mitten crab (Eriocheir sinensis), a key species in China's freshwater aquaculture, faces growing threats from Hepatopancreatic Necrosis Syndrome caused by the microsporidian parasite Hepatospora eriocheir. Deciphering the molecular mechanisms underlying host-pathogen interactions is essential for developing effective disease control strategies. While alternative splicing (AS) and alternative polyadenylation (APA) represent a critical regulatory mechanism in immune responses to pathogenic challenges, their functional significance in E. sinensis remains poorly characterized. This study employed RNA-seq to analyze hepatopancreas transcriptomes during H. eriocheir infection, systematically investigating differentially expressed genes (DEGs), AS and APA events dynamics. We identified 831 DEGs (|log2FoldChange|>= 1 and p-value < 0.05) enriched in immune-related pathways including G protein-coupled receptor signaling and epithelial morphogenesis. Additionally, 83 AS events and 914 APA events were detected, demonstrating their coordinated regulatory roles in infection responses. Our analysis revealed APA as a novel post-transcriptional modulator of host immunity, providing critical insights into molecular defense mechanisms against microsporidian invasion. These findings advance understanding of RNA processing regulation in invertebrate innate immunity and establish a framework for targeted disease management in crustacean aquaculture. |
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