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于2003-2007年，在武汉大学生命科学学院获理学学士学位；2008-2013年，在中国科学院水生生物研究所获理学博士学位，并留所工作，任助理研究员；2017年晋升为副研究员。自工作以来，面向国家重大需求，致力于阐明鱼类耐低氧和抗病性状的分子遗传机制，为鱼类抗逆和抗病新品种的培育提供理论和技术支撑。迄今，已主持了国家自然科学基金青年项目、面上项目，湖北省自然科学基金青年项目、杰出青年基金项目，中国科学院B类先导专项项目，国家重点研发计划子课题等；入选了中国科学院青年创新促进会并获得专项人才资助。此外，作为科研骨干参与了国家自然科学基金重点项目、重点研发计划、以及中国科学院A类先导专项等项目的研究工作。已发表SCI论文50篇，其中第一或通讯作者论文21篇；以第一发明人获授权发明专利3项。鉴定到SET7、SIRT5、SMYD3、PHD3、SIRT7等多个与鱼类耐低氧和抗病性状相关的关键靶标基因。基于这些靶标基因，利用CRISPR\/Cas9基因编辑技术，在草鱼、鲫、鲢和翘嘴鲌等多种养殖鱼类中，开展了抗逆、抗病新种质的创制，获得了多个耐低氧和抗病的经济鱼类新种质。获得了研究所2015年度青年科技奖、优秀论文奖；2020年度杰出创新奖和2021年度杰出创新奖；2020年度研究所首届“科研青年学者”荣誉称号，2022年入选中国科学院首批特聘研究骨干。<\/p>
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1)以斑马鱼作为模式生物，解析鱼类低氧耐受与低氧适应的遗传基础;<\/p>
2)以斑马鱼作为模式生物，解析肿瘤发生和抗病毒天然免疫的分子机制;<\/p>
3)解析低氧信号转导、细胞命运决定和抗病毒天然免疫应答的调控网络。<\/p>
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[1] Zeshan Lin#, Lei Chen#, Xianqing Chen#, Yingbin Zhong#, Yue Yang#, Wenhao Xia#, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu<\/strong>, Kjersti Sternang Kvie, Knut H？<\/span>kon R？<\/span>ed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas P. Gilbert, Qiang Qiu*, Wen Wang*, Zhipeng Li*. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364 eaav6312.<\/span><\/p> [2] Guangqing Yu#, Xing Liu<\/strong>#, Jinhua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432.<\/span><\/p> [3] Chenxi Xu, Xing Liu<\/strong>, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259.<\/span><\/p> [4] Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu<\/strong>, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380.<\/span><\/p> [5] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu<\/strong>, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017, 45(22): 12700-12714..<\/span><\/p> [6] Xing Liu<\/strong>, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749.<\/span><\/p> [7] Xing Liu<\/strong>#, Xiaolian Cai#, Bo Hu#, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.<\/span><\/p> [8] Xing Liu<\/strong>, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.<\/span><\/p> [9] Xing Liu<\/strong>, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.<\/span><\/p> [10] Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu<\/strong>, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057.<\/span><\/p> [11] Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu<\/strong>, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.<\/span><\/p> [12] Jing Wang, Wei Zhang, Wei Ji, Xing Liu<\/strong>, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.<\/span><\/p> [13] Zhu Chen, Xing Liu<\/strong>, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP\/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.<\/span><\/p> [14] Wei Zhang, Wei Ji, Xing Liu<\/strong>, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.<\/span><\/p> [15] Wei Ji, Jing Wang, Wei Zhang, Xing Liu<\/strong>, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.<\/span><\/p> [16] Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu<\/strong>, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt\/beta-catenin signaling. Development, 2013, 140: 1067-1078.<\/span><\/p> [17] Xi Feng, Xing Liu<\/strong>, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30: 3397-3415.<\/span><\/p> <\/p><\/div>"
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