于力群，中国科学院水生生物研究所研究员，博士生导师，2025入选中国科学院引才计划及国家优秀青年科学基金（海外）。2010年于武汉理工大学获理学学士学位；2013年于中国科学院水生生物研究所获得遗传学硕士学位；2019年于美国伊利诺伊大学香槟分校获生物化学博士学位；2019年-2026年在美国贝勒医学院从事博士后研究。在Cell, Immunity, Cell Stem Cell, Nature Cell Biology, Journal of Clinical Investigation, PNAS等学术期刊上发表论文20余篇。 <\/p><\/div>" var yjfx="

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1. <\/span>Yu, L.<\/span><\/strong>, Rivas, C. H., Liu, F., Shen, Y., Wu, L., Xu, Z., Ding, Y., Hao, X., Zhang, W., Chan, H. L., Liu, J., Wei, B., Gao, Y., Becerra-Dominguez, L., Wu, Y., Wang, S., Lee T., Li X., Chen X., Edwards, D. G., Zhang, X. H. F. (2026). Inflammation-and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer.<\/span> <\/strong>Journal of Clinical Investigation<\/span><\/em><\/strong>，<\/span>136 (8), e198815. <\/span><\/span><\/p>

2. <\/span>Yu, L.<\/span><\/strong>, Liebenberg, K., Shen, Y., Liu, F., Xu, Z., Hao, X., Wu, L., Zhang, W., Chan, H. L., Wei, B., Lorenzi, P. L., Gao, Y., Bado I., Becerra-Dominguez, L., Rivas, C. H., Aguirre, S., Pingel, B. C., Wu, Y., Ding, Y., Liu, J., Edwards, D. G., Eberlin, L. S., Zhang, X. H. F. (2025). Lipid-laden cancer cells transmit arachidonic acids to neutrophils to acquire resistance against combined anti-PD-1 and paclitaxel treatment.<\/span> <\/em>Immunity<\/span><\/em><\/strong>, 58 (4), 909 – 925.<\/span><\/p>

3. <\/span>Yu, L.<\/span><\/strong>, Wang, L., Kim, J. E., Mao, C., Shapiro D. J. (2020). Src Couples Estrogen Receptor to the Anticipatory Unfolded Protein Response and Regulates Cell Fate under Stress. <\/span>Biochimica et Biophysica Acta (BBA)-Molecular Cell Research<\/span><\/em><\/strong>, 1867(10), 118765.<\/span><\/p>

4. <\/span>Yu, L.<\/span><\/strong>, Wang, L., Mao, C., Duraki, D., Kim, J. E., Huang, R., Helferich, W. G., Nelson, E. R., Park, B. H., Shapiro D. J. (2019). Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations. <\/span>Cancer Letters<\/span><\/em><\/strong>, 442, 373-382.<\/span><\/p>

5. <\/span>Yu<\/span><\/strong>, L.<\/span><\/strong>, Andruska, N., Zheng, X., Shapiro, D. J. (2016). Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation. <\/span>Molecular and Cellular Endocrinology<\/span><\/em><\/strong>, 422, 31–41.<\/span><\/p>

6. <\/span>Xu, Z.,<\/span> Liu, F.,<\/span> Ding, Y.,<\/span> Pan, T., <\/span><\/span>Wu, Y., <\/span>Han, Y., Liu, J., <\/span>Bado I.,<\/span> Zhang, W., Wu, L., Gao, Y., Hao, X.,<\/span> Yu, L.<\/span><\/strong>, Li, X.,<\/span> Edwards, D. G., Chan, H. L., Aguirre, S.,<\/span><\/span> Dieffenbach, M., Chen, E., Wang, S., Shen, Y., Hoffman, D., <\/span><\/span>Becerra-Dominguez, L., Rivas, C. H.,<\/span> Chen, X., Wang, H., Kang, Y., Gugala, Z., Satcher, R., <\/span><\/span>Zhang, X. H. F. <\/span>(2026). <\/span>Unbiased niche labeling maps immune-excluded niche in bone metastasis<\/span>. <\/span>Cell<\/span><\/em><\/strong>, in press.<\/span><\/p>

7. <\/span>Zhu, J., Hao, Y., Zhang, F., Gao, X., Wang, H., <\/span>Yu, L.<\/span><\/strong>, Wang, X., Sun, Y. (2026). <\/span>Engineering Tregs-mediated immune tolerance via foxp3a overexpression to evade allograft transplantation barriers in zebrafish.<\/span> <\/em><\/strong>Journal of Genetics and Genomics<\/span><\/em><\/strong>, in press.<\/span><\/p>

8. <\/span>Liu, F.,<\/span> Ding, Y.,<\/span> Xu, Z.,<\/span> Hao, X., Pan, T., Miles, G., Wang, S., <\/span><\/span>Wu, Y.,<\/span> Liu, J., <\/span><\/span>Bado I.,<\/span> Zhang, W., Wu, L., Gao, Y.,<\/span> Yu, L.<\/span><\/strong>, <\/span>Edwards, D. G., Chan, H. L., Aguirre, S., <\/span>Dieffenbach, M., Chen, E., Shen, Y., Hoffman, D., <\/span>Becerra-Dominguez, L., Rivas, C. H.,<\/span> Chen, X., Wang, H., Kang, Y., Gugala, Satcher, R., <\/span><\/span>Zhang, X. H. F. <\/span>(2025). <\/span>Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization<\/span>. <\/span>Cell Genomics<\/span><\/em><\/strong>, 5(7):100888<\/span><\/p>

9. <\/span>Hao, X., Shen, Y., Liu, J., Alexander, A., Wu, L., Xu, Z., <\/span>Yu, L.<\/span><\/strong>, Gao, Y., Liu, F., Chan, H. L., Li, C., Ding, Y., Zhang, W., Edwards, D. G., Chen, N., Nasrazadani, A., Ueno, N. T., Lim, B., Zhang, X. H. F. (2024). Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions. <\/span>Nature Cell Biology<\/span><\/em><\/strong>, 26(11):1971-1983.<\/span><\/p>

10. <\/span>Wang, Y., Xu, Z., Wu, K. L., <\/span>Yu, L.<\/span><\/strong>, Wang, C., Ding, H., Gao, Y., Sun, H., Wu, Y., Xia, M., Chen Y., Xiao, H. (2024). Siglec-15\/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis. <\/span>Proceedings of the National Academy of Sciences<\/span><\/em><\/strong>, 121(5), e2312929121.<\/span><\/p>

11. <\/span>Hao, X., Shen, Y., Chen, N., Zhang, W., Valverde, E., Wu, L., Chan, H. L., Xu, Z., <\/span>Yu, L.<\/span><\/strong>, Gao, Y., Bado I., Michie, L. N., Rivas, C. H., Becerra-Dominguez, L., Aguirre, S., Pingel, B. C., Wu, Y., Liu, F., Ding, Y., Edwards, D. G., Liu, J., Alexander, A., Ueno, N. T., Hsueh, P., Tu, C., Liu, L., Chen, S., Hung, M., Lim, B., Zhang, X. H. F. (2023). Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. <\/span>Cell stem Cell<\/span><\/em><\/strong>, 30(5), 648-664.<\/span><\/p>

12. <\/span>Zhang, W., Bado, I., Hu, J., Wan, Y. W., Wu, L., Wang, H., Gao, Y., Jeong, H. H., Xu, Z., Hao, X., Lege, B., Al-Ouran, R., Li, L., Li, J., <\/span>Yu, L.<\/span><\/strong>, Singh, S., Lo, H., Niu, M., Zhang, X. H. F. (2021). The bone microenvironment invigorates metastatic seeds for further dissemination. <\/span>Cell<\/span><\/em><\/strong>, 184(9),<\/span> 2471-2486.<\/span><\/p>

13. <\/span>Zhang, W., Xu, Z., Hao, X., He, T., Li, J., Shen, Y., Liu, K., Gao, Y., Liu, J., Edwards, D.G., Muscarella, A.M., Wu, L., <\/span>Yu, L.<\/span><\/strong>, Xu, L., Chen, X., Wu, Y., Bado, I., Ding, Y., Aguirre, S., Wang, H., Gugala, Z., Satcher, R., Wong, S., Zhang, X. H. F. (2023). Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2<\/span>^{+<\/span><\/sup> cells. <\/span>Cancer Discovery<\/span><\/em><\/strong>, 13(2), 474-495.<\/span><\/p>}

14. <\/span>Shapiro D. J., Livezey, M., <\/span>Yu, L.<\/span><\/strong>, Zheng X., Andruska, N. (2016). Anticipatory UPR Activation: A Protective Pathway and Target in Cancer. <\/span>Trends in Endocrinology & Metabolism<\/span><\/em><\/strong>, 27(10), 731-741.<\/span><\/p>15.于力群<\/strong>，王厚鹏，朱作言，孙永华。事实上 (2014). 生长激素\/催乳素家族配体和受体成员在斑马鱼早期胚胎中的表达比较和交叉活性分析。水生生物学报，38(5): 809-818。

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