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藻类与生物制造研究中心
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中国科学院人才计划引进研究员；博士生导师、中国科学院水生生物研究所水生生物蛋白质组学课题组组长、分析测试中心主任。山东大学学士，中国科学院武汉病毒研究所硕士，新加坡国立大学博士。多年来从事功能蛋白质组学领域相关的研究工作，首次完成并报道了模式蓝藻和硅藻的蛋白质组精细图谱，建立了完整的适用于各种已经测序的模式生物蛋白基因组学分析流程；发展了基于质谱的蛋白质翻译后修饰的鉴定技术，建立了水生模式生物中蛋白质翻译后修饰的大规模、系统发现的技术方法；揭示了水生模式生物中磷酸化、乙酰化、琥珀酰化等重要蛋白质翻译后修饰在光合作用及能量代谢过程中的功能及其分子作用机制；开创了水生生物功能蛋白质组学这一新的研究领域。近年来在PNAS，Molecular Plant，New Phytologist, Plant Physiology, Molecular and Cellular Proteomics等国际专业杂志发表通讯作者论文50 多篇。担任Water Biology and Security. Frontiers in Plant Science等国际专业杂志编辑。作为课题负责人承担有国家重点研发计划项目、国家自然科学基金面上和重大研究计划项目、中科院先导等多项课题研究。目前的研究兴趣主要集中在：(1)蛋白质翻译后修饰组学及其功能研究； (2)重要模式生物的蛋白基因组学(Proteogenomics)分析；(3) 蓝细菌RNA修饰及其调控机制。<\/p><\/div>" var yjfx="

水生模式生物的功能蛋白质组学<\/p><\/div>" var hjjry="

中国科学院人才计划入选者（2010年）；<\/p>

武汉市3551人才（2015年）；<\/p>

第十四届湖北省自然科学优秀学术论文一等奖（2012年）；<\/p>

中国科学院大学—BHPB导师科研奖（2014年）；<\/p>

湖北省自然科学二等奖（排名第一）（2019年）<\/p>

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（*通讯作者）<\/span><\/strong>:<\/span><\/strong><\/span><\/p>

1. Jian Lin, Qiaoya Li, Xin Liu, Jiao Zhan, Li Yuan, Mingkun Yang, Feng Ge*<\/strong>., The role of CddA and cGNAT2 in crotonylation of proteins in cyanobacteria. New Phytologist. 2025 Sep;247(5):2270-2292.<\/span><\/p>

2. Chen Gu, Mingkun Yang, Jing Zhang, Guangying Wang, Lu Fu, Kai Chen, Lujuan Li, Peng Zhang, Shuai Luo, Fangdian Yang, Jiao Zhan, Wei Miao, Feng Ge*<\/strong>, Jie Xiong., Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymenathermophila. Molecular and Cellular Proteomics.2025;24(11):101081<\/span><\/p>

3. Kun Jia; Mingkun Yang; Xin Liu; Qi Zhang; Gaoxiang Cao; Feng Ge*<\/strong>; Jindong Zhao*; Deciphering the structure, function, and mechanism of lysine acetyltransferase cGNAT2 in cyanobacteria, Plant Physiology, 2024, 221(2)<\/span><\/p>

4. Cao G, Lin X, Ling M, Lin J, Zhang Q, Jia K, Chen B, Wei W, Wang M, Jia S, Yang M, Ge F<\/strong>*. cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria. Molecular and Cellular Proteomics. 2023 Feb 28;22(4):100521.<\/span><\/p>

5. Zhu Z, Yang M, Yang G, Zhang B, Cao X, Yuan J, Ge F*<\/strong>, Wang S*. PP2C phosphatases Ptc1 and Ptc2 dephosphorylate PGK1 to regulate autophagy and aflatoxin synthesis in the pathogenic fungus Aspergillus flavus. mBio. 2023 Oct 31;14(5):e0097723.<\/span><\/p>

6. Zhang C, Lu LF, Li ZC, Han KJ, Wang XL, Chen DD, Xiong F, Li XY, Zhou L, Ge F*<\/strong>, Li S*. Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway. Journal of Virology. 2023 Jul 27;97(7):e0053223.<\/span><\/p>

7. Liu, Xin; Yang, Mingkun; Liu, Yingfang; Ge, Feng*<\/strong>; Zhao, Jindong* ; Structural and<\/span><\/p>

Functional Insights into a Lysine Deacylase in the Cyanobacterium Synechococcus sp. PCC 7002., Plant Physiology, 2020, 184(2): 762-776 <\/span><\/p>

8. Yang M, Zhu Z, Zhuang Z, Bai Y, Wang S, Ge F*<\/strong>. Proteogenomic Characterization of the Pathogenic Fungus Aspergillus flavus Reveals Novel Genes Involved in Aflatoxin Production. Molecular and Cellular Proteomics. 2020 Dec 13;20:100013.. <\/span><\/p>

9. Lin, Xiaohuang; Yang, Mingkun; Liu, Xin; Cheng, Zhongyi; Ge, Feng*<\/strong>; Characterization of Lysine Monomethylome and Methyltransferase in Model Cyanobacterium Synechocystis sp. PCC 6803.,Genomics Proteomics Bioinformatics, 2020, 18(3): 289-304<\/span><\/p>

10. Chen Z, Zhang G, Yang M, Li T, Ge F<\/strong>*, Zhao J*. Lysine Acetylome Analysis Reveals Photosystem II Manganese-stabilizing Protein Acetylation is Involved in Negative Regulation of Oxygen Evolution in Model Cyanobacterium Synechococcus sp. PCC 7002. Molecular and Cellular Proteomics. 2017 Jul;16(7):1297-1311. <\/span><\/p>

11. Zhang J, Yang MK, Zeng H, Ge F<\/strong>*. GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes. Molecular and Cellular Proteomics. 2016 Nov;15(11):3529-3539. <\/span><\/p>

12. Zheng P, Xiong Q, Wu Y, Chen Y, Chen Z, Fleming J, Gao D, Bi L, Ge F*<\/strong>. Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells. Molecular and Cellular Proteomics. 2015 Jun;14(6):1447-63. <\/span><\/p>

13. Xiong Q, Feng J, Li ST, Zhang GY, Qiao ZX, Chen Z, Wu Y, Lin Y, Li T, Ge F<\/strong>*, Zhao JD*. Integrated transcriptomic and proteomic analysis of the global response of Synechococcus to high light stress. Molecular and Cellular Proteomics. 2015 Apr;14(4):1038-53. <\/span><\/p>

14. Yang, Mingkun; Lin, Xiaohuang; Liu, Xin; Zhang, Jia; Ge, Feng*<\/strong>; Genome Annotation of a Model Diatom Phaeodactylum tricornutum Using an Integrated Proteogenomic Pipeline., Molecular Plant, 2018, 11(10): 1292-1307<\/span><\/p>

15. Yang, Ming-kun; Yang, Yao-hua; Chen, Zhuo; Zhang, Jia; Lin, Yan; Wang, Yan; Xiong, Qian; Li, Tao*; Ge, Feng*<\/strong>; Bryant, Donald A; Zhao, Jin-dong ; Proteogenomic analysis and global discovery of posttranslational modifications in prokaryotes., PNAS, 2014, 111(52): E5633-E5642. <\/span><\/p>

<\/p><\/div>" var dh="86-27-68780500" var shrz="湖北省生化及分子生物学会常务理事；中国蛋白质组学会理事；国际专业杂志<\/span>Water Biology and Security,<\/span> Frontier in Plant Science，Current Proteomics学术编辑<\/font><\/span>" var grwy="" var xb="男" $("#EXPERT_XM").text(xm); $("#EXPERT_XB").text(xb); $("#EXPERT_ZC").text(zc); $("#EXPERT_XL").text(xl); $("#EXPERT_DH").text(dh); $("#EXPERT_DZYJ").text(dzyj); $("#EXPERT_JL").html(jl); $("#EXPERT_YJFX").html(yjfx); $("#EXPERT_ZW").html(zw); $("#EXPERT_SHRZ").html(shrz); $("#EXPERT_HJJRY").html(hjjry); $("#EXPERT_DBLZ").html(dblz); $("#EXPERT_PIC").attr("src", pic); $("title").text(xm)

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