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黄开耀，中国科学院水生生物研究所研究员、博士生导师。2004年获德国Freiburg大学分子遗传学博士学位，2010 年在美国耶鲁大学Joel Rosenbaum教授实验室完成博士后研究，2011 年回国研究团队。2012 年入选中国科学院和武汉市人才项目。<\/p>

其研究方向聚焦于藻类细胞生物学与合成生物学，重点探索纤毛、叶绿体等细胞器的形成、解聚与功能调控机制，并将相关基础发现拓展至工程化与应用领域。近年来，结合合成生物学与系统生物学等方法，推进藻源硒功能产品、虾青素及纳米级超声造影剂等生物材料的产业化研究。<\/p>

黄开耀研究员先后主持国家自然科学基金重点项目、面上项目、基金委“0–1”探索性项目、湖北省技术创新重大专项，并担任国家重点研发计划“合成生物学”方向课题负责人及中国科学院先导B项目负责人。研究成果发表在Nature、PNAS、Journal of Cell Biology、Current Biology、eLife 等国际著名学术期刊。<\/p><\/div>" var yjfx="

藻类细胞与合成生物学学科长期聚焦纤毛、叶绿体、酸钙体及气囊等重要细胞器的结构、发生与功能研究。因此通过解析细胞器形成、组装及其功能调控的分子机制，系统探究真核细胞起源、环境适应与演化的规律。在此基础上，开展细胞器的理性设计与人工构建研究，推动其在绿色制造、人类健康与现代农业等国家重大需求领域中的应用。<\/p>

一、藻类细胞生物学<\/strong><\/p>

1.纤毛膜蛋白的运输与分泌功能<\/p>

2.运动纤毛协调摆动的分子机制<\/p>

3.酸钙体的形成、演化及功能<\/p>

二、藻类合成生物学<\/strong><\/p>

1.基于内共生的细胞功能编辑<\/p>

2.工程化气囊与可视化靶向递送<\/p>

3.硒蛋白的理性设计及异源合成<\/p><\/div>" var hjjry="" var cdkyxmqk="" var dblz="

1. <\/span>L <\/span>Ye, <\/span>T. <\/span>Liao, <\/span>X <\/span>Deng, <\/span>H <\/span>Long,<\/span> G<\/span><\/span> Liu, <\/span>W. <\/span>Ke, <\/span>K. <\/span><\/strong>Huang<\/span><\/strong>*<\/span>. 2024<\/span>. Establishment of an RNA-based transient expression system in the green alga <\/span>Chlamydomonas reinhardtii<\/span><\/em>. N Biotechnol. Nov 25;83:175-187. <\/span><\/span><\/p>

2. H<\/span> Long, <\/span><\/span>J. <\/span>Fang, <\/span>L<\/span> Ye, <\/span><\/span>B. Zhang,<\/span> Colleen Hui, <\/span><\/span>X<\/span> Deng, Sabeeha S. Merchant<\/span><\/span>*<\/span>, <\/span>K. Huang<\/span><\/strong>*<\/span><\/strong>. 2023. Structural and functional regulation of lysosome-related organelles in response to environmental changes in <\/span>Chlamydomonas reinhardtii<\/span><\/em>. Plant Physiology. Mar 22:<\/span> <\/span>kiad189. <\/span><\/span><\/p>

3. <\/span>H Chen *<\/span>, <\/span>Q<\/span>. <\/span>Yang<\/span>, <\/span>J<\/span>. <\/span>Xu<\/span>,<\/span> X Deng<\/span><\/span>,<\/span> Y<\/span><\/span>. <\/span>Zhang<\/span>,<\/span> X<\/span><\/span>. <\/span>Zhang<\/span>,<\/span> T Liu<\/span><\/span>,<\/span> Rots<\/span><\/span> <\/span>Marianne<\/span>,<\/span> Xu G<\/span><\/span>.,<\/span> <\/span>K. Huang<\/span><\/strong> *<\/span><\/span><\/strong>. 2023. Efficient methods for multiple types of precise gene-editing in <\/span>Chlamydomonas<\/span><\/em>. Plant J. 2023 Aug;115(3):846-865.<\/span><\/span><\/p>

4. Zhao, L., H. Xie, Y. Kang, Y. Lin, G. Liu, M.Sakato-Antoku, Patel-King, R.S., B. Wang, C. Wan, S.M. King, C. Zhao, and <\/span>K. Huang<\/span><\/strong>. 2021. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating . <\/span>Proceedings of the National Academy of Sciences of the United States of America<\/span><\/em>.118(17):e2015689118.<\/span><\/span><\/p>

5. Yang, H., F. Zhang, H. Long, Y. Lin, J. Liao, H. Xia, and <\/span>K. Huang<\/span><\/strong>. 2021. IFT20 Mediates the Transport of Cell Migration Regulators From the Trans-Golgi Network to the Plasma Membrane in Breast Cancer Cells. <\/span>Frontiers in Cell and Developmental Biology <\/span><\/em>.<\/span><\/em>9:632198.<\/span><\/span><\/p>

6. Zhang, B., G. Duan, Y. Fang, X. Deng, Y. Yin, and <\/span>K. Huang<\/span><\/strong>. 2021. Selenium(VI) alleviates chromium(VI)-induced toxicity in the green alga <\/span>Chlamydomonas reinhardtii. <\/span><\/em>Environmental Pollution<\/span><\/em>.<\/span><\/em> 272:116407. <\/span><\/span><\/p>

7. Peng, Z., G. Liu, and <\/span>K. Huang<\/span><\/strong>. 2020. Cold Adaptation Mechanisms of a Snow Alga <\/span>Chlamydomonas nivalis <\/span><\/em>During Temperature Fluctuations. <\/span>Frontiers in Microbiology<\/span><\/em>. 11:611080.<\/span><\/span><\/p>

8. Xu, N., A. Oltmanns, L. Zhao, A. Girot, M. Karimi, L. Hoepfner, S. Kelterborn, M. Scholz, J. Beissel, P. Hegemann, O. Baumchen, L.N. Liu, <\/span>K. Huang<\/span><\/strong>, and M. Hippler. 2020. Altered N-glycan composition impacts flagella-mediated adhesion in <\/span>Chlamydomonas reinhardtii.<\/span><\/em> <\/span>Elife<\/span><\/em>. 9:e58805.<\/span><\/span><\/p>

9. Xue, J.H., G.D. Chen, F. Hao, H. Chen, Z. Fang, F.F. Chen, B. Pang, Q.L. Yang, X. Wei, Q.Q. Fan, C. Xin, J. Zhao, X. Deng, B.A. Wang, X.J. Zhang, Y. Chu, H. Tang, H. Yin, W. Ma, L. Chen, J. Ding, E. Weinhold, R.M. Kohli, W. Liu, Z.J. Zhu, <\/span>K. Huang<\/span><\/strong>, H. Tang, and G.L. Xu. 2019. A vitamin-C-derived DNA modification catalysed by an algal TET homologue. <\/span>Nature<\/span><\/em>. 569:581-585.<\/span><\/span><\/p>

10. Long, H., and <\/span>K. Huang<\/span><\/strong>. 2019. Transport of Ciliary Membrane Proteins. <\/span>Frontiers in Cell and Developmental Biology<\/span><\/em>. 7:381.<\/span><\/span><\/p>

11. Wang, Q., Z. Peng, H. Long, X. Deng, and <\/span>K. Huang<\/span><\/strong>. 2019. Polyubiquitylation of alpha-tubulin at K304 is required for flagellar disassembly in <\/span>Chlamydomonas<\/span><\/em>.<\/span> <\/span>Journal of Cell Science.<\/span><\/em> 132(6)<\/span>.<\/span><\/span><\/p>

12. Chen, T.B., G.L. Song, H.H. Yang, L. Mao, Z.B. Cui, and <\/span>K.Y. Huang<\/span><\/strong>. 2018. Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in <\/span>Zebrafish<\/span><\/em>. <\/span>Genetics<\/span><\/em>. 208:1131-1146.<\/span><\/span><\/p>

13. Cheng, X., G. Liu, W.T. Ke, L.J. Zhao, B. Lv, X.C. Ma, N.N. Xu, X.L. Xia, X. Deng, C.L. Zheng, and <\/span>K.Y. Huang<\/span><\/strong>. 2017. Building a multipurpose insertional mutant library for forward and reverse genetics in <\/span>Chlamydomonas.<\/span><\/em> <\/span>Plant Methods<\/span><\/em>. 13<\/span>:36<\/span><\/span><\/p>

14. Lv, B., L. Wan, M. Taschner, X. Cheng, E. Lorentzen, and <\/span>K. Huang<\/span><\/strong>. 2017. Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella. <\/span>Journal of Cell Science<\/span><\/em>. 130:1662-1674.<\/span><\/span><\/p>

15. Long, H., F. Zhang, N.N. Xu, G. Liu, D.R. Diener, J.L. Rosenbaum, and <\/span>K.Huang<\/span><\/strong>. 2016. Comparative Analysis of Ciliary Membranes and Ectosomes. <\/span>Current Biology<\/span><\/em>. 26:3327-3335.<\/span><\/span><\/p>

16. Hu, J.L., X. Deng, N. Shao, G.H. Wang, and <\/span>K.Huang<\/span><\/strong>. 2014. Rapid construction and screening of artificial microRNA systems in <\/span>Chlamydomonas reinhardtii.<\/span><\/em> <\/span>Plant Journal<\/span><\/em>. 79:1052-1064.<\/span><\/span><\/p>

17. Wood, C.R., <\/span>K.Y. Huang<\/span><\/strong>, D.R. Diener, and J.L. Rosenbaum. 2013. The Cilium Secretes Bioactive Ectosomes. <\/span>Current Biology<\/span><\/em>. 23:906-911.<\/span><\/span><\/p>

18. <\/span>Huang, K.<\/span><\/strong>, D.R. Diener, and J.L. Rosenbaum. 2009. The ubiquitin conjugation system is involved in the disassembly of cilia and flagella. <\/span>Journal of Cell Biology<\/span><\/em>. 186:601-613.<\/span><\/span><\/p>

19. <\/span>Huang, K<\/span><\/strong>., D.R. Diener, A. Mitchell, G.J. Pazour, G.B. Witman, and J.L. Rosenbaum. 2007. Function and dynamics of PKD2 in <\/span>Chlamydomonas reinhardtii <\/span><\/em>flagella. <\/span>Journal of Cell Biology<\/span><\/em>. 179:501-514.<\/span><\/span><\/p>

20. <\/span>Huang, K.Y.<\/span><\/strong>, T. Kunkel, and C.F. Beck. 2004. Localization of the blue-light receptor phototropin to the flagella of the green alga <\/span>Chlamydomonas reinhardtii.<\/span><\/em> <\/span>Molecular Biology of the Cell<\/span><\/em>. 15:3605-3614.<\/span><\/span><\/p>

21 Huang, K.Y.<\/span><\/strong>, and C.F. Beck. 2003. Photoropin is the blue-light receptor that controls multiple steps in the sexual life cycle of the green alga <\/span>Chlamydomonas reinhardtii<\/span><\/em>. <\/span>Proceedings of the National Academy of Sciences of the United States of America<\/span><\/em>. 100:6269-6274.<\/span><\/span><\/p>

<\/p><\/div>" var dh="86-27-68780901" var shrz="1. 武汉市产业创新研究院藻类合成生物学研究所所长

2. 湖北省合成生物学会 副理事长<\/div>
3. 中国海洋湖沼学会藻类学分会 副秘书长，理事<\/div>
4. 中国动物学会原生动物分会 理事<\/div>" var grwy="" var xb="男" $("#EXPERT_XM").text(xm); $("#EXPERT_XB").text(xb); $("#EXPERT_ZC").text(zc); $("#EXPERT_XL").text(xl); $("#EXPERT_DH").text(dh); $("#EXPERT_DZYJ").text(dzyj); $("#EXPERT_JL").html(jl); $("#EXPERT_YJFX").html(yjfx); $("#EXPERT_ZW").html(zw); $("#EXPERT_SHRZ").html(shrz); $("#EXPERT_HJJRY").html(hjjry); $("#EXPERT_DBLZ").html(dblz); $("#EXPERT_PIC").attr("src", pic); $("title").text(xm)

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